Tandem Mass Spectrometry at Mater Pathology

Tuesday, 10 June 2008

In June 2008 Mater Pathology installed its first tandem mass spectrometer—an analytical instrument used in the laboratory to identify the chemical composition of compounds or samples based on the mass to charge ratio of their particles.

The molecules of interest may first be separated chromatographically by a technique such as High Performance Liquid Chromatography (HPLC), before being ionised and introduced into the tandem mass spectrometer. Once inside the instrument, it sorts, fragments and then sorts again the ionised molecules based on their charge and size using electric and magnetic fields to do so.

The technique provides both qualitative and quantitative information about molecules of interest and has a wide range of applications including laboratory diagnostic testing, newborn screening and forensic testing.

Filed under: Pathology
    Mater Pathology Senior Scientist and coordinator of the tandem mass spectrometer, Michael Henman.

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